Refine your search
Collections
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Gupta, Sameer
- Pineal-Thymus Interrelation in Maintenance of T-Cell Dependent Immune Responses in a Tropical Seasonal Breeder Funambulus pennanti
Abstract Views :256 |
PDF Views:0
Authors
Affiliations
1 Pineal Research Laboratory, Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi - 221005, Uttar Pradesh, IN
1 Pineal Research Laboratory, Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi - 221005, Uttar Pradesh, IN
Source
Journal of Endocrinology and Reproduction, Vol 20, No 1 (2016), Pagination: 28-37Abstract
Crosstalk between the neuro-endocrine axis and immune cells is documented in many laboratory and clinical studies. The pineal gland and its hormone melatonin play a central role in this network by positively regulating immune cell proliferation and differentiation via influencing the synthesis of immunomodulatory molecules. However, the pineal-thymus interaction in modulating their bi-directional communication remains elusive. In the present study we investigated the effect of pineal-thymus interaction on the structure and functional status of lymphoid tissues (i.e., spleen and lymph nodes) in a tropical seasonal breeder, F. pennanti. We observed that pinealectomy severely compromised the immune status of the squirrels. Besides pinealectomy, simultaneous ablation of pineal and thymus gland, further resulted in atrophy of the lymphoid tissues along with reduced total leucocyte and lymphocyte count. Exogenous melatonin administration improved the total leucocyte and lymphocyte count and restored T cell dependent immune responses and lymphoid tissue architecture in pinealectomized (Px) group. Our observations suggest that suppression of endogenous melatonin in Px group decreased the efficiency of the immune system probably by modulating the production of thymic factors, which becomes even severe with simultaneous ablation of the thymus and pineal gland, resulting in declined immune responsiveness. Thus, it can be inferred that the pineal melatonin and its interaction with thymus plays an important role in regulation of immune status of the squirrels.Keywords
F. pennanti, Immunity, Lymphoid Tissues, Pinealectomy, Thymectomy.
References
- Ahmad R, Haldar C. Photoperiod-testicular-immune interaction in a seasonal breeder Indian palm squirrel Funambulus pennanti during the reproductively inactive and active phases. J Neuroendocrinol. 2009; 21:2–9
- Ben-Nathan D, Maestroni GJM, Lustig S, Conti A. Protective effect of melatonin in mice infected with encephalitis viruses. Arch Virol. 1995; 140:223–30.
- Calvo JR, Rafii-El-Idrissi M, Pozo D, Guerrero JM Immunomodulatory role of melatonin: Specific binding sites in human and rodent lymphoid cells. J Pineal Res. 1995; 18:119–26.
- Caroleo MC, Frasca D, Doria G. Melatonin as immunomodulatory in immunodeficient mice Immunopharmacology.1992; 23:81–9.
- Carrillo-Vico A, Guerrero JM, Lardone PJ, Reiter RJ. A review of the multiple actions of melatonin on the immune system. Endocrine. 2005a;.27:189–200.
- Carrillo-Vico A, Lardone PJ, Alvarez-Sánchez N, RodríguezRodríguez A, Guerrero JM. Melatonin: buffering the immune system. Int J Mol Sci. 2013; 14:8638–83.
- Carrillo-Vico A, Lardone PJ, Naji L, Fernández-Santos JM, Martín-Lacave I, Guerrero JM, Calvo JR. Beneficial pleiotropic actions of melatonin in an experimental model of septic shock in mice: regulation of pro-/anti-inflammatory cytokine network, protection against oxidative damage and anti-apoptotic effects. J Pineal Res. 2005b; 39:400–8.
- Csaba G, Barath P. Morphological changes of thymus and the thyroid gland after postnatal extirpation of pineal body.Endocrinol Exp. 1975; 9:59–67.
- Demas GE, Drazen DL, Jasnow AM, Bartness TJ, Nelson RJ. Sympathoadrenal system differentially affects photoperiodic changes in humoral immunity of Siberian hamsters (Phodopus sungorus). J Neuroendocrinol. 2002; 14:29–35.
- Goldstein AL, Guha A, Zatz MM, Hardy A, White A. Proc Natl Acad Sci USA. 1972; 69:1800–3.
- Goldstein G. Isolation of bovine thymic: A polypeptide hormone of the thymus. Nature. 1974; 247:11–4.
- Greenstein BP, Fitzpatrick FTA, Adock IM, Kendall MD, Wheller MJ. Reapearance of the thymus in old rats after orchidetomy: Inhibition of regeneration by testosterone. J endocrinol. 1986; 110:417–22.
- Greenstein BD, Adcock IMF, Kendal MD, Wheeler MJ. Reappearance of the thymus in old rats after orchidectomy; inhibition of regeneration by testosterone. J Endocrinol.1986; 110:417–22.
- Guerin, BM, Fernandez E, Behhacene N, Toribio ML, Auberger P. CD 10 is expressed on human thymic epithetial cell lines and modulates thymopoietin induced cell proliferation.Faseb Journal. 1997; 11(12):1003–11.
- Guerrero JM, Reiter RJ. A brief survey of pineal gland-immune system interrelationships. Endocrinol Res. 1992; 18:91–113.
- Guerrero JM, Reiter RJ. A brief survey of pineal gland–immune system interrelationships. Endocr Res. 1992; 18:91– 113.
- Gupta S, Haldar C. Physiological crosstalk between melatonin and glucocorticoid receptor modulates T-cell mediated immune responses in a wild tropical rodent. Funambulus pennant. J Steroid Biochem Mol Biol. 2013; 134:23–36.
- Gupta S, Haldar C. Photoperiodic modulation of local melatonin synthesis and its role in regulation of thymic homeostasis in Funambulus pennanti. Gen Comp Endocrinol.2015; 15:30044–7.
- Haldar C, Hausler D, Gupta D. Effect of the pineal gland on circadian rhythmicity of colony forming units for granulocytes and macrophages (CFU-GM) from rat bone marrow cell cultures. J Pineal Res. 1992; 12:79–83.
- Haldar, Mishra C. Method of pinealectomy in some vertebrates.Ind J Exp Biol. 1986; 24:319–22.
- Haldar C, Saxena N. Antigonadotropic activity of pineal gland of the Indian palm squirrel Funambulus pennant. Indian J Exp Biol. 1989; 27:421–3.
- Haldar C, Singh R. Pineal modulation of thymus and immune function in a seasonally breeding tropical rodent, Funambulus pennant. J Exp Zool. 2001; 289:90–8.
- Haldar C, Singh R, Guchhait P. Relationship between the annual rhythms in melatonin and immune system status in the tropical palm squirrel, Funambulus pennant. Chronobiol Int. 2001; 18:61–9.
- Haldar C, Rai S, Singh R. Melatonin blocks dexamethasoneinduced immunosuppression in a seasonally breeding rodent Indian palm squirrel, Funambulus pennant. Steroids.2004; 69:367–77.
- Icten N, Kargoz F, Gunec KA. The effects of constant darkness and constant light on the pineal gland and thymus morphology in rats. Tr J Medical Sciences. 1998; 28:7–12.
- Jankovic BD, Isakovic K, Horvat J. Effect of a lipid fraction from rat thymus on delayed hypersensitivity reactions of neonatally thymectomized rats. Nature. 1970; 208:256–7.
- Kay M. The thymus: Clock for immunologic aging? J Invest Dermatol. 1979. 73:29–38.
- Kuci S, Becker J, Veit G, Handgretinger R, Attanasio A, Bruchelt G, Treuner J, Niethammer D, Gupta D. Circadian variation in the immunomodulatory role of the pineal gland. Neuroendocrinol Let. 1988; 10:65–79.
- Lissoni P, Barni S, Ardizzoia A, Paolorassi F, Crispino S, Tancini G, Tisi E, Architis C, De Toma D, Pipino G, Conti A, Maestroni GJM. Randomized study with pineal hormones versus supportive care alone in advanced non- small cell lung cancer resistant to first – line chemotherapy containing cisplastin . Oncology. 1992; 49:336.
- Lochmiller RL, Ditchkoff SS. Environmental influences on mass dynamics of the cotton rat (Sigmodon hispidus) thymus gland. Biol Rhy Res. 1999; 29:206–12.
- Maestroni GJM, Conti A, Lissoni A. Hematopoietic rescue via T-cell dependent endogenous GM–CSF by the pineal neurohormone melatonin in tumor bearing mice. Cancer Res. 1994; 54:2429–32.
- Maestroni GJM, Conti A, Lissoni P. Colony stimulating activity and hematopoietic rescue from cancer chemotherapy compounds are induced by melatonin via endogenous interleukin4. Cancer Res. 1994; 54:4740–3.
- Maestroni GJM, Conti A, Pierpaoli W. The pineal gland and the circadian opiatergic immunoregulatory role of melatonin.Ann N Y Acad Sci. 1987; 521:140–8.
- Maestroni GJM, Conti A, Pierpaoli W. Role of pineal gland in immunity. II. Melatonin enhances the antibody response via an opiatergic mechanism. Clin Exp Immunol. 1987; 68:384–91.
- Maestroni GJM, Flamigni LF, Hertens H, Conti A. Biochemical and functional characterization of melatonin- inducedopioids in spleen and bone marrow T- helper cells.Neuroendocrinol Lett. 1995; 17:145–52.
- Maestroni GJM. T-helper-2 lymphocytes as a peripheral target of melatonin. J Pineal Res. 1995; 18:84–9.
- Maestroni GJM. The immunoneuroendocrine role of melatonin.J Pineal Res. 1993; 14:1–10.
- Maestroni GJM, Flamigni LF, Hertens H, Conti A. Biochemical and functional characterization of melatonin–induced– opioids in spleen and been marrow T-helper cells.Neuroendocrinol Lett. 1995; 17:145–52.
- Makindoan T, Key MMB. Age influence on the immune system. Ads Immunol. 1980; 29:287–330.
- Martin LB, Weil ZM, Nelson RJ. Seasonal changes in vertebrate immune activity: Mediation by physiological tradeoffs.Philos Trans R Soc Lond B Biol Sci. 2008; 363:321–39.
- Kumar N, Shan L-X, Hardy MP, Bardin CW, Sundaram K.Mechanism of Androgen –Induced thymolysis in rats. Endocrinology.1995; 36(11):4887–93.
- Osoba D, Millar JFAP. The lymphoid tissues and immune responsiveness of neonatally thymectomized mice bearing thymus tissues in millipore diffusion chambers. J Exp Med.1964; 119:177–94.
- Pioli C, Carleo C, Nistico G, Doria G. Melatonin increases antigen presentation and amplifies specific and non-specific signals for T-cell proliferation. Int G Immunopharmacol.1993; 15:463–8.
- Poon AM, Pang SF. 2[125I] iodomelatonin binding sites in spleens of guinea pigs. Life Sci. 1992; 50:1719–26.
- Rafii-el-Idrissi M, Calvo JR, Pozo D, Harmouch A, Guerrero JM. Specific binding of [125I] iodomelatonin by rat splenocytes: Characterization and its role on regulation of cyclic AMP production. J Neuroimmunol. 1995; 57:171–8.
- Rella W, Lapin V. Immunocompetence of pinealectomized and simultaneously pinealecyomized and thymectomized rats. Oncology. 1976; 33:3–8.
- Savino W, Dardenne M. Neuroendocrine control of thymus physiology. Endocr Rev. 2000; 21:412–43.
- Tian YM, Zhang GY, Dai YR. Melatonin rejuvenates degenerated thymus and redresses peripheral immune functions in aged mice. Immunol Lett. 2003; 88:101–4.
- Vishwas DK, Haldar C. Photoperiodic induced melatonin regulates immunity and expression pattern of melatonin receptor MT1 in spleen and bone marrow mononuclear cells of male golden hamster. J Photochem Photobiol B. 2013c; 128:107–14.
- Yao Q, Doan LX, Zhang R, Bharadwaj U, Li M, Chen C.Thymosin-alpha1 modulates dendritic cell differentiation and functional maturation from human peripheral blood CD14+ monocytes. Immunol Lett. 2007; 110(2):110–20.
- Zatz MM, Godstein AL. Thymosins, lymphokines and the immunology of aging. Gerontology. 1985; 31:263–72.
- Oral Administration of Root Extract of Boerhaavia diffusa Mitigates Diabetes-induced Kidney Damages in the Golden Hamster Mesocricetus auratus
Abstract Views :139 |
PDF Views:0
Authors
Affiliations
1 Pineal Research Laboratory, Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi – 221005, Uttar Pradesh, India ., IN
2 Department of Dravyagun, Institute of Medical Science, Banaras Hindu University, Varanasi – 221005, Uttar Pradesh, India ., IN
3 Kalinga Institute of Social Sciences-Deemed University, Bhubaneshwar – 751024, Odisha, India ., IN
1 Pineal Research Laboratory, Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi – 221005, Uttar Pradesh, India ., IN
2 Department of Dravyagun, Institute of Medical Science, Banaras Hindu University, Varanasi – 221005, Uttar Pradesh, India ., IN
3 Kalinga Institute of Social Sciences-Deemed University, Bhubaneshwar – 751024, Odisha, India ., IN
Source
Journal of Endocrinology and Reproduction, Vol 26, No 3 (2022), Pagination: 164-170Abstract
Diabetes, a common metabolic disorder, is affecting people irrespective of age group and/or gender. The chronic hyperglycemia during diabetes leads to heart-, kidney-, eye- and nerve damages. Boerhaavia diffusa, commonly known as Punarnava, is one of the traditional medicines described in Ayurveda for the treatment of a number of diseases. B. diffusa has been reported to exhibit antidiabetic, diuretic, anti-inflammatory, hepatoprotective, and immunomodulatory properties. The present study was carried out to evaluate the anti-hyperglycemic potential of ethanolic extract of root of B. diffusa and its effect on diabetes-induced kidney damage in hamster model. Treatment of ethanolic extract of B. diffusa resulted in significant reduction in the serum glucose level and increased insulin concentration with a simultaneous increment in the levels of muscle and liver glycogen. The oral supplementation of B. diffusa root extract improved lipid profile by reducing the cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and by increasing high density lipoprotein cholesterol (HDL-C). The activity of antioxidant enzymes Superoxide Dismutase (SOD) and Catalase (CAT) in the kidney significantly improved following oral administration of B. diffusa while a significant decrease in Lipid Peroxidation (LPO) level was noted in the kidney after the treatment. Ethanolic root extract of B. diffusa decreased the level of serum creatinine, urea and Alkaline Phosphatase (ALP) significantly. B. diffusa administration demonstrated marked improvement in renal histology as evident by the regenerative changes in glomerulus and Bowman’s capsule. Thus, the use of ethanolic extract of Boerhaavia diffusa may prove therapeutically effective in prevention as well as inhibition of the progression of diabetes and associated kidney damages.Keywords
Boerhaavia diffusa, Diabetes, Diabetic Nephropathy, Hamsters, PunarnavaReferences
- Arora S, Haldar C. Diabetes: Rescue by Boerhaavia diffusa. Journal of Endocrinology and Reproduction. 2018; 22(2):1-3.
- Alam P, Shahzad N, Gupta AK, Mahfoz AM, Bamagous GA, Al-Ghamdi SS, Siddiqui NA. Anti-diabetic effect of Boerhavia diffusa L. root extract via free radical scavenging and antioxidant mechanism. Toxicology and Environmental Health Sciences. 2018; 10(3):220-227. https://doi.org/10.1007/s13530-018-0367-z
- Chauhan SK, Thapliyal RP, Ojha SK, Rai H, Singh P, Singh M. Antidiabetic and antioxidant effect of ethanolic root extract of Boerhaavia diffusa in streptozotocin-induced diabetic rats. Journal of Pharmacy Research. 2011; 4(2):446-448.
- Malhotra D, Ishaq F, Khan A. Antihyperglycemic activity of Boerhaavia diffusa in streptozotocin induced diabetic rats. International Journal of Chemical and Analytical Sciences. 2014; 5(1):21-23.
- Satheesh MA, Pari L. Antioxidant effect of Boerhavia diffusa L. in tissues of alloxan induced diabetic rats. Indian Journal Experimental Biology. 2004; 42(10):989-992. https://doi.org/10.1300/J044v10n04_11
- Nalamolu RK, Boini KM, Nammi S. Effect of chronic administration of Boerhaavia diffusa Linn. leaf extract on experimental diabetes in rats. Tropical Journal of Pharmaceutical Research. 2004; 3(1):305-309. https://doi.org/10.4314/tjpr.v3i1.14614
- Murti K, Lambole V, Panchal M, Kumar U. Antidiabetic and antihyperlipidemic activity of roots of Boerhaavia diffusa on streptozotocin induced diabetic rats. Pharmacologyonline. 2011; 1:15-21.
- Pareta SK, Patra KC, Mazumder PM, Sasmal D. Aqueous extract of Boerhaavia diffusa root ameliorates ethylene glycol-induced hyperoxaluric oxidative stress and renal injury in rat kidney. Pharmaceutical Biology. 2011; 49(12): 1224-1233. https://doi.org/10 .3109/13880209.2011.581671 PMid:21846174
- Sawardekar SB, Patel TC. Evaluation of the effect of Boerhavia diffusa on gentamicin-induced nephrotoxicity in rats. Journal of Ayurveda and integrative medicine. 2015; 6(2):95-103. https://doi.org/10.4103/0975-9476.146545 PMid:26166999 PMCid:PMC4484055
- Indhumathi T, Shilpa K, Mohandass S. Evaluation of nephroprotective role of Boerhaavia diffusa leaves against mercuric chloride induced toxicity in experimental rats. Journal of Pharmacy Research. 2011; 4(6):1848-1850.
- Pareta SK, Patra KC, Harwansh R, Kumar M, Meena KP. Protective effects of Boerhaavia diffusa against acetaminophen-induced nephrotoxicity in rats. PharmacologyOnline. 2011; 2:698-706 (b).
- Oburai NL, Rao VV, Bonath RB. Comparative clinical evaluation of Boerhavia diffusa root extract with standard Enalapril treatment in Canine chronic renal failure. Journal of Ayurveda and integrative medicine. 2015; 6(3):150-157. https://doi.org/10.4103/09759476.166390 PMid:26604549 PMCid:PMC4630688
- Akhter F, Alvi SS, Ahmad P, Iqbal D, Alshehri BM, Khan MS. Therapeutic efficacy of Boerhaavia diffusa (Linn.) root methanolic extract in attenuating streptozotocin-induced diabetes, diabetes-linked hyperlipidemia and oxidative-stress in rats. Biomedical research and therapy. 2019; 6(7):3293-3306. https://doi.org/10.15419/bmrat.v6i7.556
- Mandal S, Bapna JS. Pharmacological evaluation of Boerhavia diffusa plant extract for their potential in management of diabetic nephropathy in streptozotocin induced type diabetic rats. World Journal of Pharmacy and Pharmaceutical Sciences. 2016; 5(12): 1097-1108.
- Singh PK, Baxi D, Doshi A, Ramachandran AV. Antihyperglycaemic and renoprotective effect of Boerhaavia diffusa L. in experimental diabetic rats. Journal of Complementary and Integrative Medicine. 2011; 8:(1). https://doi.org/10.2202/15533840.1533 PMid:22754925
- Motawi TK, Ahmed SA, Hamed MA, El-Maraghy SA, Aziz WM. Combination of melatonin and certain drugs for treatment of diabetic nephropathy in streptozotocin-induced diabetes in rats. Diabetology International. 2016; 7(4):413-424. https://doi. org/10.1007/s13340-016-0268-9 PMid:30603294 PMCid:PMC6224965
- Das K, Samanta L, Chainy GBN. A modified spectrophotometric assay of superoxide dismutase using nitrite formation by superoxide radicals. Indian Journal of Expeerimental Biology 2000; 37(3):201-204
- Sinha AK. Colorimetric assay of catalase. Analytical Biochemistry. 1972; 47(2):389-394. https://doi.org/10.1016/00032697(72)90132-7
- Ohkawa H, Ohishi N, Yagi K. Reaction of linoleic acid hydroperoxide with thiobarbituric acid. Journal of Lipid Research. 1978; 19(8):1053-1057. https://doi.org/10.1016/S0022-2275(20)40690-X
- Jasmine R. Restoration of liver and muscle glycogen by Eugenia jambolina in diabetic rats. International Journal of Research in Pharmacy and Biosciences. 2014; 1(2):16-21. https://doi.org/10.17812/IJPER/2014;1(3):16-21
- Shajeela PS, Kalpanadevi V, Mohan VR. Potential antidiabetic, hypo lipidaemic and antioxidant effects of Nymphaea pubescens extract in alloxan induced diabetic rats. J Appl Pharmaceut. Sci. 2012;2(2):83-88.
- Soliman AM. Potential impact of Paracentrotus lividus extract on diabetic rat models induced by high fat diet/streptozotocin.Journal of Basic and Applied Zoology 2016; 77:8-20. https://doi.org/10.1016/j.jobaz.2016.01.001
- Mathur A, Mathur R. Study of association of serum lipids with diabetic retinopathy in type 2 diabetes mellitus. People’s Journal of Scientific Research 2013; 6(1):25-28.
- Leighton E, Sainsbury CA, Jones GC. A practical review of C-peptide testing in diabetes. Diabetes Therapy 2017; 8(3):475-487. https://doi.org/10.1007/s13300-017-0265-4 PMid:28484968 PMCid:PMC5446389
- Gu Q, Feng T, Cao H. Tang Y, Ge X, Luo J, Xue J, Wu J, Yang H, Zhang S, Cao J. HIV-TAT mediated protein transduction of Cu/Zn-superoxide dismutase-1(SOD-1) protects skin cells from ionizing radiation. Radiation Oncology 2013; 8:253.https://doi. org/10.1186/1748-717X-8-253 PMid:24175971 PMCid:PMC3839640
- Kumar G, Banu GS, Murugesan AG, Pandian MR. Antihyperglycemic and antiperoxidative effect of Heicteres igora l. bark extracts in streptozotocin-induced diabetic rats. J Appl Biomed. 2007; 5:97-104. https://doi.org/10.32725/jab.2007.014
- Tian W, Lei H, Guan R, Xu Y, Li H, Wang L, Yang B, Gao Z, Xin Z. Icariside II ameliorates diabetic nephropathy in streptozotocin-induced rats. Drug Des Devel Ther. 2015; 9:5147-5157. https://doi.org/10.2147/DDDT.S90060 PMid:26379427 PMCid:PMC4567177
- Zhang S, Xu H, Yu X, Wang Y, Sun F, Sui D. Simvastatin ameliorates low-dose streptozotocin-induced type 2 diabetic nephropathy in an experimental rat model. Int J Clin Exp Med. 2015; 8(4):6388-6396.
- Veeramani C, Pushpavalli G, Pugalendi KV. Antihyperglycemic effect of Cardiospermum halicacabum Linn. leaf extrac on streptozotocin induced diabetic rats. J Appl Biomed. 2008; 6:19-26. https://doi.org/10.32725/jab.2008.003
- Sharma A, Hirulkar NB, Wadel P, Da P. Detection of renal function parameters urea and creatinine. Int J Pharmaceut Biol Arch. 2011; 2(2):734-739.
- Gowda S, Desai PB, Kulkarni SS, Hull VV, Math KA, Vernekar SN. Markers of renal function tests. N Am J Med Sci. 2010; 2(4):170-173.
- Kaleem M, Medha Ahmed QU, Asif M, Bano B. Benaficial effects of Annona squamosa extract in streptozotocin-induced diabetic rats. Singapore Med. J. 2008; 49(10):800-804.
- Alibawi FN, Al-Morshidy SY, Alhuweizi AG. The Alkaline Phosphatase Levels in the Seminal Plasma and Sperms of Sub-fertile Patients and Normospermic Men. InInternational Conference on Applied Life Sciences. 2012 Sep 10. IntechOpen.